The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation

The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation

Blog Article

B-cell activation plays a crucial part in the immune system Apple Cider Vinegar and is initiated via interaction between the B cell receptor (BCR) and specific antigens.In recent years with the help of modern imaging techniques, it was found that the cortical actin cytoskeleton changes dramatically during B-cell activation.In this review, we discuss how actin-cytoskeleton reorganization regulates BCR signaling in different stages of B-cell activation, specifically when stimulated by antigens, and also how this reorganization is mediated by BCR signaling molecules.Abnormal BCR signaling is associated with the progression of lymphoma Ball - Bag - Team and immunological diseases including autoimmune disorders, and recent studies have proved that impaired actin cytoskeleton can devastate the normal activation of B cells.Therefore, to figure out the coordination between the actin cytoskeleton and BCR signaling may reveal an underlying mechanism of B-cell activation, which has potential for new treatments for B-cell associated diseases.